AirHint found the following cheapest return flights from San Francisco (SFO) to Rome (FCO) in October 2025 (see full year).

Return flights

24 Oct - 10 Nov	Frontier Airlines
07 Oct - 14 Oct	Alaska Airlines
27 Oct - 03 Nov	British Airways
07 Oct - 21 Oct	British Airways
30 Oct - 13 Nov	British Airways
28 Oct - 04 Nov	Alaska Airlines
07 Oct - 20 Oct	Frontier Airlines
03 Oct - 17 Oct	British Airways
08 Oct - 19 Oct	Condor
08 Oct - 20 Oct	Condor
02 Oct - 12 Oct	Condor
24 Oct - 01 Nov	Frontier Airlines
30 Oct - 06 Nov	ITA Airways	direct
30 Oct - 13 Nov	ITA Airways	direct
27 Oct - 03 Nov	ITA Airways	direct
21 Oct - 28 Oct	SWISS
08 Oct - 21 Oct	Condor
02 Oct - 17 Oct	Iberia
24 Oct - 10 Nov	ITA Airways	direct
25 Oct - 01 Nov	United

Also check the deals for one-way flights from San Francisco to Rome in October.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from San Francisco to Rome in October from 424€

Return flights