AirHint found the following cheapest one-way flights from San Francisco (SFO) to Rome (FCO) in October 2025 (see full year).

One-Way flights

22 Oct	Frontier Airlines
04 Oct	Frontier Airlines
20 Oct	Alaska Airlines
13 Oct	TAP
08 Oct	Frontier Airlines
17 Oct	Alaska Airlines
22 Oct	ITA Airways	direct
17 Oct	ITA Airways	direct
13 Oct	United	direct
08 Oct	ITA Airways	direct

Also check the deals for return flights from San Francisco to Rome in October.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest one-way flights from San Francisco to Rome in October from 211€

One-Way flights