AirHint found the following cheapest return flights from Santo Domingo (SDQ) to Madrid (MAD) in September 2025 (see full year).

Return flights

29 Sep - 06 Oct	Spirit Airlines
26 Sep - 09 Oct	Spirit Airlines
26 Sep - 23 Oct	Spirit Airlines
21 Sep - 19 Oct	Spirit Airlines
27 Sep - 30 Sep	Spirit Airlines
29 Sep - 05 Oct	Spirit Airlines
27 Sep - 24 Oct	jetBlue
21 Sep - 12 Oct	Spirit Airlines
23 Sep - 30 Sep	Arajet
24 Sep - 28 Sep	Spirit Airlines
28 Sep - 05 Oct	Spirit Airlines
29 Sep - 08 Oct	Spirit Airlines
24 Sep - 30 Oct	Arajet
19 Sep - 28 Sep	Arajet
16 Sep - 30 Sep	Spirit Airlines
18 Sep - 25 Sep	Spirit Airlines
18 Sep - 30 Sep	Spirit Airlines
20 Sep - 27 Sep	Spirit Airlines
14 Sep - 21 Sep	Spirit Airlines
18 Sep - 22 Sep	Spirit Airlines

Also check the deals for one-way flights from Santo Domingo to Madrid in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Santo Domingo to Madrid in September from 627€

Return flights