AirHint found the following cheapest one-way flights from Santo Domingo (SDQ) to Madrid (MAD) in September 2025 (see full year).

One-Way flights

29 Sep	Spirit Airlines
26 Sep	Spirit Airlines
28 Sep	Spirit Airlines
30 Sep	Arajet
21 Sep	Spirit Airlines
27 Sep	Spirit Airlines
23 Sep	Arajet
20 Sep	Spirit Airlines
24 Sep	Arajet
25 Sep	Spirit Airlines

Also check the deals for return flights from Santo Domingo to Madrid in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest one-way flights from Santo Domingo to Madrid in September from 286€

One-Way flights