AirHint found the following cheapest return flights from Santiago (SCQ) to Prague (PRG) in December 2025 (see full year).

Return flights

01 Dec - 04 Dec	Vueling Airlines
03 Dec - 04 Dec	Vueling Airlines
03 Dec - 08 Dec	Vueling Airlines
19 Dec - 22 Dec	Vueling Airlines
26 Dec - 30 Dec	Vueling Airlines
13 Dec - 30 Dec	Vueling Airlines
10 Dec - 30 Dec	Vueling Airlines
12 Dec - 30 Dec	Vueling Airlines
01 Dec - 08 Dec	Vueling Airlines

Also check the deals for one-way flights from Santiago to Prague in December.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Santiago to Prague in December from 192€

Return flights