AirHint found the following cheapest return flights from Santiago (SCQ) to Prague (PRG) in December 2025 (see full year).

Return flights

12 Dec - 15 Dec	Vueling Airlines
07 Dec - 13 Dec	Vueling Airlines
11 Dec - 15 Dec	Vueling Airlines
02 Dec - 06 Dec	Vueling Airlines
02 Dec - 15 Dec	Vueling Airlines
08 Dec - 15 Dec	Vueling Airlines
07 Dec - 15 Dec	Vueling Airlines
13 Dec - 15 Dec	Vueling Airlines
14 Dec - 15 Dec	Vueling Airlines
13 Dec - 16 Dec	Vueling Airlines
20 Dec - 06 Jan	Vueling Airlines

Also check the deals for one-way flights from Santiago to Prague in December.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Santiago to Prague in December from 157€

Return flights