AirHint found the following cheapest return flights from Santiago (SCL) to Panama City (PTY) in December 2025 (see full year).

Return flights

05 Dec - 14 Dec	Avianca
03 Dec - 10 Dec	Avianca
02 Dec - 10 Dec	Avianca
16 Dec - 23 Dec	Copa	direct
22 Dec - 28 Dec	Copa	direct
05 Dec - 08 Dec	Copa	direct
01 Dec - 04 Dec	Copa	direct
01 Dec - 05 Dec	Copa	direct
15 Dec - 23 Dec	Copa	direct
03 Dec - 12 Dec	Copa	direct
28 Dec - 08 Jan	Copa	direct
17 Dec - 04 Jan	Copa	direct
06 Dec - 03 Jan	Copa	direct
21 Dec - 11 Jan	Copa	direct
05 Dec - 03 Jan	Copa	direct
27 Dec - 05 Jan	Copa	direct
29 Dec - 04 Jan	Copa	direct
26 Dec - 06 Jan	Copa	direct
30 Dec - 07 Jan	Copa	direct

Also check the deals for one-way flights from Santiago to Panama City in December.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

Book a cheap hotel in Panama City

Cheap car rent in Panama City

Cheapest return flights from Santiago to Panama City in December from 403€

Return flights