AirHint found the following cheapest return flights from Santiago (SCL) to Panama City (PTY) in December 2025 (see full year).

Return flights

31 Dec - 04 Jan	Avianca
31 Dec - 05 Jan	Avianca
31 Dec - 11 Jan	Avianca
26 Dec - 12 Jan	Avianca
25 Dec - 29 Dec	Avianca
25 Dec - 28 Dec	Avianca
27 Dec - 01 Jan	Avianca
31 Dec - 04 Jan	Copa	direct
31 Dec - 05 Jan	Copa	direct
31 Dec - 11 Jan	Copa	direct
22 Dec - 29 Dec	LATAM Airlines Group
23 Dec - 28 Dec	Copa	direct
25 Dec - 29 Dec	Copa	direct
25 Dec - 28 Dec	Copa	direct
26 Dec - 06 Jan	Copa	direct
26 Dec - 12 Jan	Copa	direct
19 Dec - 29 Dec	Avianca
22 Dec - 28 Dec	Avianca
22 Dec - 28 Dec	Copa	direct
22 Dec - 29 Dec	Copa	direct

Also check the deals for one-way flights from Santiago to Panama City in December.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Santiago to Panama City in December from 454€

Return flights