Cheapest one-way flights from Santiago to Panama City in December from 253€

AirHint found the following cheapest one-way flights from Santiago (SCL) to Panama City (PTY) in December 2025 (see full year).

One-Way flights

10 Dec JetSmart
15 Dec Avianca
17 Dec Avianca
01 Dec Avianca
22 Dec Avianca
26 Dec Avianca
22 Dec Copa direct
10 Dec Copa direct
15 Dec Copa direct
26 Dec Copa direct

Also check the deals for return flights from Santiago to Panama City in December.

Skyscanner

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

Book a cheap hotel in Panama City

Cheap car rent in Panama City

Feel free to contact us with any feedback or request another flight research.