AirHint found the following cheapest return flights from Santiago (SCL) to Madrid (MAD) in September 2025 (see full year).

Return flights

26 Sep - 27 Oct	Avianca
28 Sep - 24 Oct	Avianca
21 Sep - 30 Sep	Sky Airline
25 Sep - 30 Sep	Sky Airline
20 Sep - 30 Sep	Avianca
19 Sep - 30 Sep	Sky Airline
29 Sep - 14 Oct	Avianca
30 Sep - 14 Oct	Avianca
26 Sep - 12 Oct	Avianca
17 Sep - 07 Oct	Avianca
30 Sep - 24 Oct	Avianca
23 Sep - 15 Oct	Avianca
29 Sep - 15 Oct	Avianca
30 Sep - 20 Oct	Avianca
05 Sep - 11 Sep	Sky Airline
20 Sep - 27 Sep	LATAM Airlines Group
22 Sep - 30 Sep	LATAM Airlines Group
03 Sep - 09 Sep	LATAM Airlines Group
23 Sep - 30 Sep	LATAM Airlines Group
06 Sep - 13 Sep	LATAM Airlines Group

Also check the deals for one-way flights from Santiago to Madrid in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Santiago to Madrid in September from 752€

Return flights