AirHint found the following cheapest return flights from Panama City (PTY) to Mexico City (MEX) in December 2025 (see full year).

Return flights

20 Dec - 03 Jan	Aeromexico	direct
04 Dec - 09 Dec	Avianca
04 Dec - 08 Dec	Avianca
11 Dec - 08 Jan	Avianca
28 Dec - 05 Jan	Copa	direct
01 Dec - 16 Dec	Copa	direct
15 Dec - 09 Jan	Copa	direct
31 Dec - 06 Jan	Avianca
09 Dec - 23 Dec	Aeromexico	direct
11 Dec - 08 Jan	Aeromexico	direct
04 Dec - 09 Dec	Copa	direct
04 Dec - 08 Dec	Copa	direct
31 Dec - 06 Jan	Copa	direct
07 Dec - 11 Dec	Avianca
29 Dec - 02 Jan	Avianca
12 Dec - 19 Dec	Copa	direct
29 Dec - 02 Jan	Copa	direct

Also check the deals for one-way flights from Panama City to Mexico City in December.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Panama City to Mexico City in December from 269€

Return flights