AirHint found the following cheapest return flights from Panama City (PTY) to Mexico City (MEX) in December 2025 (see full year).

Return flights

24 Dec - 31 Dec	Aeromexico	direct
24 Dec - 03 Jan	Copa	direct
20 Dec - 31 Dec	Aeromexico	direct
17 Dec - 31 Dec	Aeromexico	direct
21 Dec - 31 Dec	Aeromexico	direct
23 Dec - 01 Jan	Aeromexico	direct
28 Dec - 01 Jan	Avianca
30 Dec - 04 Jan	Copa	direct
27 Dec - 03 Jan	Copa	direct
20 Dec - 04 Jan	Copa	direct
28 Dec - 05 Jan	Copa	direct
20 Dec - 05 Jan	Copa	direct
13 Dec - 20 Dec	Aeromexico	direct
10 Dec - 17 Dec	Copa	direct
19 Dec - 22 Dec	Copa	direct
17 Dec - 21 Dec	Copa	direct
28 Dec - 03 Jan	Copa	direct
11 Dec - 13 Dec	Aeromexico	direct
10 Dec - 14 Dec	Aeromexico	direct
28 Dec - 01 Jan	Copa	direct

Also check the deals for one-way flights from Panama City to Mexico City in December.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

Book a cheap hotel in Mexico City

Cheap car rent in Mexico City

Cheapest return flights from Panama City to Mexico City in December from 235€

Return flights