AirHint found the following cheapest return flights from Panama City (PTY) to Mexico City (MEX) in December 2025 (see full year).

Return flights

24 Dec - 31 Dec	Aeromexico	direct
25 Dec - 31 Dec	Aeromexico	direct
24 Dec - 01 Jan	Aeromexico	direct
30 Dec - 03 Jan	Copa	direct
30 Dec - 04 Jan	Copa	direct
02 Dec - 10 Dec	Copa	direct
17 Dec - 31 Dec	Avianca
12 Dec - 13 Dec	Avianca
07 Dec - 11 Dec	Avianca
21 Dec - 31 Dec	Avianca
04 Dec - 08 Dec	Avianca
04 Dec - 07 Dec	Avianca
19 Dec - 22 Dec	Aeromexico	direct
29 Dec - 03 Jan	Aeromexico	direct
20 Dec - 17 Jan	Aeromexico
20 Dec - 18 Jan	Aeromexico
28 Dec - 05 Jan	Avianca
20 Dec - 17 Jan	Copa	direct
20 Dec - 18 Jan	Copa	direct
27 Dec - 03 Jan	Copa	direct

Also check the deals for one-way flights from Panama City to Mexico City in December.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Panama City to Mexico City in December from 230€

Return flights