Cheapest return flights from Panama City to Madrid in September from 635€

Best time to book flights for Panama City (PTY) to Madrid (MAD) flights at AirHint

AirHint found the following cheapest return flights from Panama City (PTY) to Madrid (MAD) in September 2025 (see full year).

Return flights

16 Sep - 26 Sep Air France
22 Sep - 08 Oct KLM
17 Sep - 28 Sep Air Europa direct
19 Sep - 24 Sep Air Europa direct
16 Sep - 26 Sep Air Europa direct
08 Sep - 08 Oct KLM
13 Sep - 28 Sep Air Europa direct
07 Sep - 21 Sep Air France
30 Sep - 14 Oct Air France
07 Sep - 14 Sep Air France
02 Sep - 15 Sep Air France
09 Sep - 24 Sep Air Europa direct
08 Sep - 12 Sep Iberia direct

Also check the deals for one-way flights from Panama City to Madrid in September.

Skyscanner

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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