Cheapest return flights from Panama City to Madrid in September from 734€

Best time to book flights for Panama City (PTY) to Madrid (MAD) flights at AirHint

AirHint found the following cheapest return flights from Panama City (PTY) to Madrid (MAD) in September 2025 (see full year).

Return flights

26 Sep - 14 Oct Air Europa direct
18 Sep - 09 Oct Iberia direct
13 Sep - 21 Sep Air Europa direct
13 Sep - 28 Sep Air Europa direct
25 Sep - 13 Oct Iberia direct
27 Sep - 15 Oct Air Europa direct
30 Sep - 15 Oct Air Europa direct
14 Sep - 01 Oct Air Europa direct
01 Sep - 15 Sep Iberia direct
01 Sep - 15 Oct Air Europa direct
01 Sep - 16 Sep Avianca

Also check the deals for one-way flights from Panama City to Madrid in September.

Skyscanner

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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