AirHint found the following cheapest return flights from Panama City (PTY) to Madrid (MAD) in September 2025 (see full year).

Return flights

22 Sep - 13 Oct	Air Europa	direct
18 Sep - 29 Sep	Avianca
16 Sep - 19 Sep	Avianca
12 Sep - 19 Sep	Air France
06 Sep - 25 Sep	Air France
12 Sep - 21 Sep	Air France
11 Sep - 19 Sep	Air France
26 Sep - 30 Oct	Avianca
09 Sep - 29 Sep	Air France
10 Sep - 29 Sep	Air France
06 Sep - 27 Sep	Air France
07 Sep - 27 Sep	Air France
14 Sep - 04 Oct	Turkish Airlines
13 Sep - 03 Oct	Air France
14 Sep - 03 Oct	Air France
12 Sep - 03 Oct	Air France
11 Sep - 03 Oct	Air France
09 Sep - 03 Oct	Air France
10 Sep - 03 Oct	Air France
06 Sep - 03 Oct	Air France

Also check the deals for one-way flights from Panama City to Madrid in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Panama City to Madrid in September from 595€

Return flights