Cheapest return flights from Panama City to Madrid in December from 618€

AirHint found the following cheapest return flights from Panama City (PTY) to Madrid (MAD) in December 2025 (see full year).

Return flights

24 Dec - 16 Jan Avianca
29 Dec - 25 Jan Air France
30 Dec - 13 Jan Air France
27 Dec - 25 Jan Air France
27 Dec - 25 Jan Air Europa direct
02 Dec - 16 Dec Turkish Airlines
25 Dec - 04 Jan Air France
24 Dec - 16 Jan Air Europa direct
01 Dec - 25 Dec Air France
01 Dec - 15 Dec Air Europa direct
08 Dec - 15 Dec Air Europa direct
09 Dec - 23 Dec Air France
26 Dec - 03 Jan Air France
20 Dec - 17 Jan Air Europa direct
21 Dec - 11 Jan Air France
16 Dec - 29 Dec Air France
06 Dec - 22 Dec Iberia direct
02 Dec - 16 Dec Air Europa direct
19 Dec - 29 Dec KLM
19 Dec - 29 Dec Air Europa direct

Also check the deals for one-way flights from Panama City to Madrid in December.

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The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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