Cheapest return flights from Panama City to Madrid in December from 723€

Best time to book flights for Panama City (PTY) to Madrid (MAD) flights at AirHint

AirHint found the following cheapest return flights from Panama City (PTY) to Madrid (MAD) in December 2025 (see full year).

Return flights

08 Dec - 02 Jan Air France
29 Dec - 05 Jan Air France
26 Dec - 21 Jan KLM
26 Dec - 21 Jan Air Europa direct
26 Dec - 11 Jan KLM
29 Dec - 05 Jan Iberia direct
10 Dec - 13 Jan Air France
13 Dec - 02 Jan Air France
16 Dec - 04 Jan Air France
16 Dec - 03 Jan Air France
10 Dec - 24 Dec Iberia direct
10 Dec - 27 Dec Iberia direct
06 Dec - 20 Dec Air France
06 Dec - 19 Dec Air France

Also check the deals for one-way flights from Panama City to Madrid in December.

Skyscanner

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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