Cheapest return flights from Panama City to Madrid in December from 578€

AirHint found the following cheapest return flights from Panama City (PTY) to Madrid (MAD) in December 2025 (see full year).

Return flights

03 Dec - 21 Jan Air France
13 Dec - 25 Jan Avianca
10 Dec - 28 Jan Avianca
10 Dec - 27 Jan Avianca
09 Dec - 28 Jan Avianca
10 Dec - 29 Jan Avianca
11 Dec - 19 Jan Avianca
02 Dec - 18 Jan Avianca
11 Dec - 20 Jan Avianca
03 Dec - 17 Jan Avianca
06 Dec - 12 Dec Air Europa direct
01 Dec - 11 Dec Avianca
05 Dec - 12 Dec Air Europa direct
03 Dec - 08 Dec Iberia direct
01 Dec - 24 Dec Air France
01 Dec - 25 Dec Air France
01 Dec - 25 Dec Air Europa direct
16 Dec - 31 Dec Air France
01 Dec - 28 Dec Air France
16 Dec - 30 Dec Air France

Also check the deals for one-way flights from Panama City to Madrid in December.

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