Cheapest return flights from Panama City to Madrid in December from 714€

Best time to book flights for Panama City (PTY) to Madrid (MAD) flights at AirHint

AirHint found the following cheapest return flights from Panama City (PTY) to Madrid (MAD) in December 2025 (see full year).

Return flights

09 Dec - 03 Jan KLM
08 Dec - 11 Jan KLM
22 Dec - 08 Jan KLM
21 Dec - 09 Jan KLM
08 Dec - 11 Jan Air Europa direct
09 Dec - 16 Dec Air Europa direct
22 Dec - 28 Dec Turkish Airlines
22 Dec - 28 Dec Air Europa direct

Also check the deals for one-way flights from Panama City to Madrid in December.

Skyscanner

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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