Cheapest one-way flights from Panama City to Madrid in December from 433€

AirHint found the following cheapest one-way flights from Panama City (PTY) to Madrid (MAD) in December 2025 (see full year).

One-Way flights

05 Dec KLM
06 Dec Turkish Airlines
24 Dec Avianca
29 Dec Air France
15 Dec Wingo
29 Dec Air Europa direct
06 Dec Air Europa direct
24 Dec Air Europa direct
15 Dec Copa direct
05 Dec Air Europa direct

Also check the deals for return flights from Panama City to Madrid in December.

Skyscanner

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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