Cheapest one-way flights from Panama City to Madrid in December from 429€

AirHint found the following cheapest one-way flights from Panama City (PTY) to Madrid (MAD) in December 2025 (see full year).

One-Way flights

02 Dec Air Europa direct
05 Dec Air Europa direct
04 Dec Air France
09 Dec Air France
01 Dec Copa
01 Dec Air Europa direct
08 Dec Air Europa direct
09 Dec Air Europa direct
24 Dec Avianca
23 Dec Avianca

Also check the deals for return flights from Panama City to Madrid in December.

Powered by

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

Book a cheap hotel in Madrid

Cheap car rent in Madrid

Feel free to contact us with any feedback or request another flight research.