Cheapest one-way flights from Panama City to Madrid in December from 489€
AirHint found the following cheapest one-way flights from Panama City (PTY) to Madrid (MAD) in December 2025 (see full year).
One-Way flights
| 08 Dec | Avianca | ||
| 08 Dec | Air Europa | direct | |
| 09 Dec | Air Europa | direct |
Also check the deals for return flights from Panama City to Madrid in December.
The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.
