Cheapest one-way flights from Panama City to Madrid in December from 383€

AirHint found the following cheapest one-way flights from Panama City (PTY) to Madrid (MAD) in December 2025 (see full year).

One-Way flights

08 Dec Turkish Airlines
06 Dec Turkish Airlines
04 Dec Turkish Airlines
05 Dec Turkish Airlines
09 Dec Turkish Airlines
24 Dec KLM
25 Dec KLM
17 Dec Wingo
20 Dec Avianca
11 Dec Avianca

Also check the deals for return flights from Panama City to Madrid in December.

Skyscanner

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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