AirHint found the following cheapest return flights from Prague (PRG) to Istanbul (IST) in December 2025 (see full year).

Return flights

13 Dec - 22 Dec	Pegasus Airlines	direct
03 Dec - 17 Dec	Pegasus Airlines	direct
11 Dec - 14 Dec	Pegasus Airlines
09 Dec - 17 Dec	LOT
12 Dec - 16 Dec	LOT
04 Dec - 07 Dec	LOT
29 Dec - 02 Jan	Pegasus Airlines	direct
19 Dec - 24 Dec	LOT
19 Dec - 26 Dec	LOT
09 Dec - 17 Dec	Pegasus Airlines	direct
24 Dec - 30 Dec	LOT
20 Dec - 11 Jan	LOT
26 Dec - 05 Jan	Air Serbia
30 Dec - 03 Jan	Pegasus Airlines	direct
26 Dec - 03 Jan	Air Serbia
18 Dec - 03 Jan	LOT
26 Dec - 05 Jan	Pegasus Airlines	direct
18 Dec - 03 Jan	Pegasus Airlines	direct
30 Dec - 09 Jan	Fly One
23 Dec - 09 Jan	Fly One

Also check the deals for one-way flights from Prague to Istanbul in December.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Prague to Istanbul in December from 139€

Return flights