AirHint found the following cheapest one-way flights from Prague (PRG) to Istanbul (IST) in December 2025 (see full year).

One-Way flights

31 Dec	Pegasus Airlines	direct
03 Dec	Pegasus Airlines	direct
04 Dec	Pegasus Airlines	direct
09 Dec	Pegasus Airlines	direct
30 Dec	Pegasus Airlines	direct
08 Dec	Pegasus Airlines	direct
01 Dec	Pegasus Airlines	direct
02 Dec	Pegasus Airlines	direct
11 Dec	Fly One
06 Dec	Pegasus Airlines	direct

Also check the deals for return flights from Prague to Istanbul in December.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest one-way flights from Prague to Istanbul in December from 62€

One-Way flights