AirHint found the following cheapest return flights from Chicago (ORD) to Panama City (PTY) in December 2025 (see full year).

Return flights

04 Dec - 10 Dec	Spirit Airlines
09 Dec - 15 Jan	Spirit Airlines
12 Dec - 14 Dec	Spirit Airlines
11 Dec - 16 Dec	Copa	direct
04 Dec - 10 Dec	Copa	direct
05 Dec - 13 Dec	Copa	direct
04 Dec - 18 Dec	Copa	direct
09 Dec - 15 Jan	Copa	direct
18 Dec - 22 Dec	United
01 Dec - 10 Dec	United
01 Dec - 10 Dec	Copa	direct
24 Dec - 28 Dec	United
27 Dec - 06 Jan	Copa	direct
22 Dec - 02 Jan	Frontier Airlines
20 Dec - 04 Jan	Frontier Airlines
20 Dec - 04 Jan	Copa	direct
22 Dec - 02 Jan	Copa	direct

Also check the deals for one-way flights from Chicago to Panama City in December.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

Book a cheap hotel in Panama City

Cheap car rent in Panama City

Cheapest return flights from Chicago to Panama City in December from 446€

Return flights