AirHint found the following cheapest return flights from Chicago (ORD) to Panama City (PTY) in December 2025 (see full year).

Return flights

29 Dec - 12 Jan	Copa	direct
18 Dec - 26 Dec	Copa	direct
18 Dec - 27 Dec	Copa	direct
16 Dec - 22 Dec	Copa	direct
27 Dec - 09 Jan	Copa	direct
25 Dec - 28 Dec	Delta
10 Dec - 14 Dec	Spirit Airlines
24 Dec - 28 Dec	Spirit Airlines
10 Dec - 14 Dec	Copa	direct
23 Dec - 28 Dec	United
22 Dec - 28 Dec	United
26 Dec - 30 Dec	Spirit Airlines
24 Dec - 01 Jan	Spirit Airlines
25 Dec - 01 Jan	Frontier Airlines
26 Dec - 01 Jan	Spirit Airlines
27 Dec - 05 Jan	Spirit Airlines
31 Dec - 05 Jan	Avianca
29 Dec - 03 Jan	Spirit Airlines
27 Dec - 05 Jan	Copa	direct
31 Dec - 05 Jan	Copa	direct

Also check the deals for one-way flights from Chicago to Panama City in December.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Chicago to Panama City in December from 452€

Return flights