AirHint found the following cheapest return flights from Chicago (ORD) to Panama City (PTY) in December 2025 (see full year).

Return flights

13 Dec - 20 Dec	Copa	direct
24 Dec - 29 Dec	Avianca
24 Dec - 29 Dec	Copa	direct
28 Dec - 02 Jan	Avianca
27 Dec - 03 Jan	Avianca
28 Dec - 04 Jan	Volaris
21 Dec - 04 Jan	Frontier Airlines
28 Dec - 04 Jan	Copa	direct
22 Dec - 04 Jan	Copa	direct
28 Dec - 02 Jan	Copa	direct
27 Dec - 03 Jan	Copa	direct
21 Dec - 04 Jan	Copa	direct

Also check the deals for one-way flights from Chicago to Panama City in December.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Chicago to Panama City in December from 384€

Return flights