Cheapest one-way flights from Chicago to Panama City in December from 144€

AirHint found the following cheapest one-way flights from Chicago (ORD) to Panama City (PTY) in December 2025 (see full year).

One-Way flights

11 Dec Spirit Airlines
13 Dec Spirit Airlines
07 Dec Spirit Airlines
31 Dec Spirit Airlines
16 Dec Spirit Airlines
26 Dec Avianca
22 Dec Spirit Airlines
11 Dec Copa direct
07 Dec Copa direct
31 Dec Copa direct

Also check the deals for return flights from Chicago to Panama City in December.

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The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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