AirHint found the following cheapest return flights from Miami (MIA) to Santiago (SCL) in October 2025 (see full year).

Return flights

23 Oct - 26 Oct	Sky Airline
10 Oct - 14 Oct	Sky Airline
23 Oct - 03 Nov	Sky Airline
24 Oct - 03 Nov	Sky Airline
28 Oct - 02 Nov	Sky Airline
27 Oct - 03 Nov	Sky Airline
02 Oct - 18 Oct	Sky Airline
04 Oct - 11 Oct	Sky Airline
20 Oct - 27 Oct	Sky Airline
11 Oct - 18 Oct	Sky Airline
20 Oct - 01 Nov	Sky Airline
06 Oct - 13 Oct	Avianca
01 Oct - 21 Oct	Delta
02 Oct - 14 Oct	Delta	direct
23 Oct - 03 Nov	Delta	direct
27 Oct - 03 Nov	Delta	direct
20 Oct - 01 Nov	Delta	direct
02 Oct - 18 Oct	Delta	direct

Also check the deals for one-way flights from Miami to Santiago in October.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Miami to Santiago in October from 375€

Return flights