AirHint found the following cheapest return flights from Mexico City (MEX) to Santiago (SCL) in December 2025 (see full year).

Return flights

01 Dec - 11 Dec	Avianca
01 Dec - 09 Dec	Avianca
01 Dec - 15 Dec	Avianca
02 Dec - 09 Dec	Avianca
01 Dec - 10 Dec	Volaris
03 Dec - 10 Dec	Avianca
04 Dec - 10 Dec	Avianca
08 Dec - 15 Dec	Avianca
02 Dec - 10 Dec	Arajet
02 Dec - 14 Dec	Arajet
25 Dec - 01 Jan	Avianca
01 Dec - 08 Jan	Avianca
27 Dec - 08 Jan	Avianca
03 Dec - 08 Jan	Avianca
24 Dec - 07 Jan	Avianca
20 Dec - 01 Jan	Avianca
24 Dec - 06 Jan	Avianca
10 Dec - 06 Jan	Avianca
25 Dec - 05 Jan	Avianca
26 Dec - 08 Jan	Aeromexico

Also check the deals for one-way flights from Mexico City to Santiago in December.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Mexico City to Santiago in December from 436€

Return flights