AirHint found the following cheapest return flights from Mexico City (MEX) to Santiago (SCL) in December 2025 (see full year).

Return flights

07 Dec - 16 Dec	Avianca
01 Dec - 08 Dec	Avianca
01 Dec - 05 Dec	Avianca
16 Dec - 22 Jan	Avianca
02 Dec - 09 Dec	Avianca
02 Dec - 16 Dec	Avianca
02 Dec - 22 Jan	Avianca
04 Dec - 15 Dec	Volaris
19 Dec - 13 Jan	Avianca
01 Dec - 07 Dec	Avianca
01 Dec - 10 Dec	LATAM Airlines Group
02 Dec - 10 Dec	Copa
09 Dec - 23 Dec	LATAM Airlines Group	direct
02 Dec - 22 Jan	Aeromexico	direct
25 Dec - 06 Jan	Avianca
18 Dec - 08 Jan	Avianca
26 Dec - 08 Jan	Avianca
18 Dec - 06 Jan	Avianca
22 Dec - 06 Jan	Avianca
19 Dec - 06 Jan	Avianca

Also check the deals for one-way flights from Mexico City to Santiago in December.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Mexico City to Santiago in December from 450€

Return flights