AirHint found the following cheapest return flights from Mexico City (MEX) to Santiago (SCL) in December 2025 (see full year).

Return flights

11 Dec - 24 Dec	Arajet
03 Dec - 24 Dec	Avianca
04 Dec - 10 Dec	Avianca
03 Dec - 10 Dec	Avianca
04 Dec - 11 Dec	Avianca
09 Dec - 24 Dec	Avianca
05 Dec - 12 Dec	Copa
05 Dec - 19 Dec	Copa
04 Dec - 16 Dec	Copa
06 Dec - 17 Dec	Copa
24 Dec - 01 Jan	Copa
07 Dec - 14 Jan	Arajet
25 Dec - 01 Jan	LATAM Airlines Group
31 Dec - 13 Jan	LATAM Airlines Group
09 Dec - 14 Jan	Arajet
30 Dec - 23 Jan	LATAM Airlines Group	direct
24 Dec - 27 Jan	Aeromexico
23 Dec - 20 Jan	LATAM Airlines Group	direct
23 Dec - 01 Jan	LATAM Airlines Group
29 Dec - 19 Jan	Avianca

Also check the deals for one-way flights from Mexico City to Santiago in December.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

Book a cheap hotel in Santiago

Cheap car rent in Santiago

Cheapest return flights from Mexico City to Santiago in December from 359€

Return flights