Cheapest one-way flights from Mexico City to Santiago in December from 219€

AirHint found the following cheapest one-way flights from Mexico City (MEX) to Santiago (SCL) in December 2025 (see full year).

One-Way flights

04 Dec Arajet
05 Dec Avianca
03 Dec Avianca
15 Dec Avianca
19 Dec Avianca
22 Dec Avianca
20 Dec Avianca
18 Dec Avianca
21 Dec Avianca
15 Dec LATAM Airlines Group direct

Also check the deals for return flights from Mexico City to Santiago in December.

Skyscanner

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

Book a cheap hotel in Santiago

Cheap car rent in Santiago

Feel free to contact us with any feedback or request another flight research.