AirHint found the following cheapest return flights from Mexico City (MEX) to Santiago (SCL) in October 2025 (see full year).

Return flights

31 Oct - 10 Nov	Avianca
29 Oct - 11 Nov	Avianca
13 Oct - 20 Oct	Volaris
01 Oct - 07 Oct	Arajet
18 Oct - 28 Oct	Avianca
18 Oct - 12 Nov	Avianca
23 Oct - 06 Nov	Avianca
18 Oct - 13 Nov	Avianca
02 Oct - 28 Oct	Avianca
03 Oct - 28 Oct	Avianca
14 Oct - 28 Oct	Avianca
21 Oct - 03 Nov	Avianca
17 Oct - 04 Nov	Avianca
02 Oct - 09 Oct	Copa
06 Oct - 13 Oct	Copa
01 Oct - 08 Oct	Copa
24 Oct - 01 Nov	Avianca
01 Oct - 14 Oct	Copa
25 Oct - 01 Nov	Avianca
23 Oct - 01 Nov	Avianca

Also check the deals for one-way flights from Mexico City to Santiago in October.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Mexico City to Santiago in October from 450€

Return flights