AirHint found the following cheapest return flights from Mexico City (MEX) to Santiago (SCL) in October 2025 (see full year).

Return flights

07 Oct - 20 Oct	Arajet
07 Oct - 13 Oct	Arajet
03 Oct - 11 Oct	Avianca
04 Oct - 12 Oct	Avianca
12 Oct - 18 Oct	Avianca
09 Oct - 18 Oct	Avianca
04 Oct - 11 Oct	Avianca
06 Oct - 09 Oct	Avianca
01 Oct - 05 Oct	Avianca
02 Oct - 09 Oct	Avianca
21 Oct - 10 Nov	Avianca
28 Oct - 04 Nov	Avianca
30 Oct - 06 Nov	Avianca
22 Oct - 06 Nov	Avianca
31 Oct - 10 Nov	Avianca
18 Oct - 03 Nov	Copa
26 Oct - 02 Nov	Copa
24 Oct - 02 Nov	Copa
17 Oct - 02 Nov	Copa
06 Oct - 25 Nov	Copa

Also check the deals for one-way flights from Mexico City to Santiago in October.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Mexico City to Santiago in October from 388€

Return flights