AirHint found the following cheapest return flights from Mexico City (MEX) to Panama City (PTY) in December 2025 (see full year).

Return flights

04 Dec - 11 Dec	Avianca
04 Dec - 08 Dec	Avianca
31 Dec - 13 Jan	Avianca
30 Dec - 13 Jan	Copa	direct
30 Dec - 17 Jan	Copa	direct
31 Dec - 13 Jan	Copa	direct
03 Dec - 09 Dec	Aeromexico	direct
30 Dec - 08 Jan	Copa	direct
25 Dec - 31 Dec	Aeromexico	direct
25 Dec - 30 Dec	Aeromexico	direct
25 Dec - 01 Jan	Aeromexico	direct
04 Dec - 12 Dec	Avianca
09 Dec - 16 Dec	Avianca
11 Dec - 16 Dec	Avianca
08 Dec - 13 Dec	Avianca
08 Dec - 11 Dec	Avianca
16 Dec - 15 Jan	Aeromexico	direct
30 Dec - 09 Jan	Aeromexico	direct
31 Dec - 05 Jan	Copa	direct
31 Dec - 07 Jan	Copa	direct

Also check the deals for one-way flights from Mexico City to Panama City in December.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Mexico City to Panama City in December from 223€

Return flights