AirHint found the following cheapest return flights from Mexico City (MEX) to Panama City (PTY) in December 2025 (see full year).

Return flights

31 Dec - 05 Jan	Copa	direct
31 Dec - 15 Jan	Copa	direct
31 Dec - 13 Jan	Copa	direct
02 Dec - 08 Dec	Avianca
31 Dec - 09 Jan	Aeromexico	direct
02 Dec - 10 Dec	Avianca
04 Dec - 07 Dec	Avianca
04 Dec - 10 Dec	Avianca
04 Dec - 08 Dec	Avianca
11 Dec - 24 Dec	Avianca
06 Dec - 24 Dec	Avianca
09 Dec - 15 Dec	Avianca
11 Dec - 19 Dec	Avianca
06 Dec - 14 Dec	Avianca
31 Dec - 07 Jan	Aeromexico
30 Dec - 14 Jan	Aeromexico	direct
31 Dec - 08 Jan	Aeromexico
15 Dec - 24 Jan	Aeromexico	direct
24 Dec - 01 Jan	Copa	direct
29 Dec - 07 Jan	Avianca

Also check the deals for one-way flights from Mexico City to Panama City in December.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Mexico City to Panama City in December from 228€

Return flights