AirHint found the following cheapest return flights from Mexico City (MEX) to Panama City (PTY) in December 2025 (see full year).

Return flights

01 Dec - 09 Dec	Avianca
05 Dec - 08 Dec	Avianca
05 Dec - 13 Dec	Avianca
13 Dec - 17 Dec	Avianca
31 Dec - 05 Jan	Avianca
31 Dec - 04 Jan	Avianca
30 Dec - 04 Jan	Avianca
18 Dec - 22 Dec	Avianca
15 Dec - 26 Dec	Avianca
27 Dec - 07 Jan	Aeromexico	direct
22 Dec - 29 Dec	Avianca
15 Dec - 24 Jan	Aeromexico	direct
24 Dec - 31 Dec	Aeromexico
24 Dec - 31 Dec	Copa	direct
15 Dec - 26 Dec	Copa	direct
29 Dec - 05 Jan	Avianca
30 Dec - 06 Jan	Aeromexico	direct
20 Dec - 16 Jan	Avianca
19 Dec - 04 Jan	Avianca
20 Dec - 08 Jan	Avianca

Also check the deals for one-way flights from Mexico City to Panama City in December.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Mexico City to Panama City in December from 262€

Return flights