AirHint found the following cheapest return flights from Mexico City (MEX) to Panama City (PTY) in December 2025 (see full year).

Return flights

27 Dec - 07 Jan	Aeromexico	direct
13 Dec - 10 Jan	Aeromexico	direct
03 Dec - 09 Dec	Avianca
11 Dec - 15 Dec	Aeromexico	direct
17 Dec - 21 Dec	Aeromexico	direct
03 Dec - 09 Dec	Aeromexico	direct
15 Dec - 19 Dec	Aeromexico	direct
14 Dec - 18 Dec	Aeromexico	direct
26 Dec - 05 Jan	Copa	direct
29 Dec - 05 Jan	Copa	direct
15 Dec - 04 Jan	Copa	direct
19 Dec - 23 Dec	Copa	direct
27 Dec - 03 Jan	Copa	direct
21 Dec - 27 Dec	Aeromexico	direct
20 Dec - 04 Jan	Copa	direct
05 Dec - 10 Dec	Avianca
29 Dec - 29 Dec	Avianca

Also check the deals for one-way flights from Mexico City to Panama City in December.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

Book a cheap hotel in Panama City

Cheap car rent in Panama City

Cheapest return flights from Mexico City to Panama City in December from $312

Return flights