AirHint found the following cheapest return flights from Mexico City (MEX) to Panama City (PTY) in December 2025 (see full year).

Return flights

24 Dec - 13 Jan	Aeromexico	direct
10 Dec - 17 Dec	Aeromexico	direct
09 Dec - 16 Dec	Aeromexico	direct
24 Dec - 30 Dec	Aeromexico	direct
24 Dec - 31 Dec	Aeromexico	direct
24 Dec - 05 Jan	Aeromexico
24 Dec - 01 Jan	Aeromexico	direct
25 Dec - 13 Jan	Copa	direct
25 Dec - 12 Jan	Copa	direct
24 Dec - 05 Jan	Copa	direct
23 Dec - 30 Dec	Avianca
20 Dec - 30 Dec	Avianca
06 Dec - 14 Dec	Copa	direct
21 Dec - 30 Dec	Avianca
05 Dec - 07 Dec	Avianca
06 Dec - 12 Dec	Avianca
27 Dec - 10 Jan	Avianca
30 Dec - 10 Jan	Avianca
23 Dec - 01 Jan	Avianca
23 Dec - 02 Jan	Avianca

Also check the deals for one-way flights from Mexico City to Panama City in December.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Mexico City to Panama City in December from 264€

Return flights