Cheapest return flights from Mexico City to Panama City in December from $312

AirHint found the following cheapest return flights from Mexico City (MEX) to Panama City (PTY) in December 2025 (see full year).

Return flights

27 Dec - 07 Jan Aeromexico direct
13 Dec - 10 Jan Aeromexico direct
03 Dec - 09 Dec Avianca
11 Dec - 15 Dec Aeromexico direct
17 Dec - 21 Dec Aeromexico direct
03 Dec - 09 Dec Aeromexico direct
15 Dec - 19 Dec Aeromexico direct
14 Dec - 18 Dec Aeromexico direct
26 Dec - 05 Jan Copa direct
29 Dec - 05 Jan Copa direct
15 Dec - 04 Jan Copa direct
19 Dec - 23 Dec Copa direct
27 Dec - 03 Jan Copa direct
21 Dec - 27 Dec Aeromexico direct
20 Dec - 04 Jan Copa direct
05 Dec - 10 Dec Avianca
29 Dec - 29 Dec Avianca

Also check the deals for one-way flights from Mexico City to Panama City in December.

Skyscanner

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

Book a cheap hotel in Panama City

Cheap car rent in Panama City

Feel free to contact us with any feedback or request another flight research.