AirHint found the following cheapest return flights from Madrid (MAD) to Santa Cruz (VVI) in September 2025 (see full year).

Return flights

17 Sep - 17 Oct	Avianca
17 Sep - 14 Oct	Iberia	direct
24 Sep - 23 Oct	Iberia	direct
15 Sep - 15 Oct	Avianca
21 Sep - 16 Oct	Avianca
20 Sep - 14 Oct	Avianca
26 Sep - 11 Oct	Avianca
28 Sep - 11 Oct	Avianca
27 Sep - 11 Oct	Avianca
16 Sep - 13 Oct	Avianca
21 Sep - 29 Sep	Avianca
15 Sep - 29 Sep	Avianca
17 Sep - 29 Sep	Avianca
19 Sep - 29 Sep	Avianca
15 Sep - 28 Sep	Avianca
17 Sep - 22 Sep	Avianca
22 Sep - 28 Sep	Avianca
18 Sep - 25 Sep	Avianca
17 Sep - 21 Sep	Avianca
15 Sep - 26 Sep	Avianca

Also check the deals for one-way flights from Madrid to Santa Cruz in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Madrid to Santa Cruz in September from 713€

Return flights