AirHint found the following cheapest return flights from Madrid (MAD) to Santa Cruz (VVI) in September 2025 (see full year).

Return flights

12 Sep - 26 Sep	Avianca
10 Sep - 25 Sep	Avianca
03 Sep - 23 Sep	Avianca
14 Sep - 28 Sep	Avianca
13 Sep - 27 Sep	Avianca
01 Sep - 24 Sep	Avianca
21 Sep - 28 Sep	Avianca
01 Sep - 28 Sep	Avianca
06 Sep - 27 Sep	Avianca
21 Sep - 08 Oct	Avianca
21 Sep - 07 Oct	Avianca
14 Sep - 29 Sep	Avianca
15 Sep - 15 Oct	Avianca
14 Sep - 01 Oct	Avianca
03 Sep - 08 Oct	Avianca
07 Sep - 07 Oct	Avianca
09 Sep - 09 Oct	Avianca
10 Sep - 28 Oct	Avianca
08 Sep - 28 Oct	Avianca
04 Sep - 06 Oct	Avianca

Also check the deals for one-way flights from Madrid to Santa Cruz in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Madrid to Santa Cruz in September from 684€

Return flights