Cheapest one-way flights from Madrid to Santa Cruz in September from 451€

Best time to book flights for Madrid (MAD) to Santa Cruz (VVI) flights at AirHint

AirHint found the following cheapest one-way flights from Madrid (MAD) to Santa Cruz (VVI) in September 2025 (see full year).

One-Way flights

19 Sep LATAM Airlines Group
17 Sep LATAM Airlines Group
10 Sep LATAM Airlines Group
15 Sep LATAM Airlines Group
14 Sep LATAM Airlines Group
09 Sep LATAM Airlines Group
01 Sep LATAM Airlines Group
16 Sep Avianca
19 Sep Air Europa direct
17 Sep Air Europa direct

Also check the deals for return flights from Madrid to Santa Cruz in September.

Skyscanner

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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