AirHint found the following cheapest return flights from Madrid (MAD) to Panama City (PTY) in September 2025 (see full year).

Return flights

16 Sep - 16 Oct	Avianca
22 Sep - 22 Oct	Avianca
10 Sep - 30 Sep	KLM
21 Sep - 30 Sep	Air France
15 Sep - 16 Oct	KLM
19 Sep - 11 Oct	KLM
18 Sep - 14 Oct	KLM
02 Sep - 02 Oct	KLM
10 Sep - 30 Sep	Air Europa	direct
08 Sep - 29 Sep	Air Europa	direct
15 Sep - 29 Sep	KLM
15 Sep - 16 Oct	Iberia	direct
15 Sep - 21 Sep	Air Europa	direct
10 Sep - 23 Sep	Air Europa	direct
21 Sep - 30 Sep	Air Europa	direct
22 Sep - 30 Sep	Air Europa	direct
07 Sep - 21 Sep	Air Europa	direct
23 Sep - 02 Oct	KLM
30 Sep - 08 Oct	Air France
22 Sep - 22 Oct	Air Europa	direct

Also check the deals for one-way flights from Madrid to Panama City in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Madrid to Panama City in September from 561€

Return flights