AirHint found the following cheapest return flights from Madrid (MAD) to Panama City (PTY) in September 2025 (see full year).

Return flights

17 Sep - 06 Oct	KLM
20 Sep - 06 Oct	KLM
20 Sep - 06 Oct	Iberia	direct
16 Sep - 21 Sep	Air France
17 Sep - 21 Sep	KLM
22 Sep - 06 Oct	Air France
18 Sep - 21 Sep	KLM
15 Sep - 30 Sep	TAP
22 Sep - 06 Oct	Iberia	direct
22 Sep - 19 Oct	Air France
17 Sep - 29 Sep	Vueling Airlines
20 Sep - 01 Oct	Vueling Airlines
19 Sep - 04 Oct	KLM
17 Sep - 24 Sep	Vueling Airlines
18 Sep - 25 Sep	Air France
20 Sep - 29 Sep	Vueling Airlines
24 Sep - 02 Oct	Air Europa
17 Sep - 06 Oct	Air Europa	direct
17 Sep - 22 Sep	Vueling Airlines
23 Sep - 27 Sep	Transavia France

Also check the deals for one-way flights from Madrid to Panama City in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Madrid to Panama City in September from 486€

Return flights