AirHint found the following cheapest return flights from Madrid (MAD) to Panama City (PTY) in September 2026 (see full year).

Return flights

10 Sep - 27 Sep	Avianca
15 Sep - 27 Sep	Avianca
11 Sep - 20 Sep	Air Europa	direct
26 Sep - 04 Oct	Air France
03 Sep - 16 Sep	Avianca
06 Sep - 19 Sep	Avianca
12 Sep - 20 Sep	Avianca
12 Sep - 19 Sep	Avianca
03 Sep - 20 Sep	Avianca
10 Sep - 26 Sep	Avianca
01 Sep - 22 Sep	Avianca
24 Sep - 07 Oct	Air France
24 Sep - 07 Oct	Air Europa	direct
26 Sep - 03 Oct	Air France
26 Sep - 03 Oct	Air Europa	direct

Also check the deals for one-way flights from Madrid to Panama City in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Madrid to Panama City in September from 576€

Return flights