Cheapest one-way flights from Madrid to Panama City in September from 231€

AirHint found the following cheapest one-way flights from Madrid (MAD) to Panama City (PTY) in September 2025 (see full year).

One-Way flights

16 Sep Ryanair
15 Sep TAP
20 Sep Vueling Airlines
18 Sep Air Europa direct
19 Sep Air Europa direct
20 Sep Air Europa direct
24 Sep Air Europa direct
29 Sep Iberia direct
26 Sep Iberia direct
15 Sep Air Europa direct

Also check the deals for return flights from Madrid to Panama City in September.

Skyscanner

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

Book a cheap hotel in Panama City

Cheap car rent in Panama City

Feel free to contact us with any feedback or request another flight research.