AirHint found the following cheapest return flights from Madrid (MAD) to Panama City (PTY) in August 2025 (see full year).

Return flights

26 Aug - 29 Sep	KLM
24 Aug - 24 Sep	Air Europa	direct
25 Aug - 24 Sep	Air Europa	direct
26 Aug - 24 Sep	Air Europa	direct
23 Aug - 24 Sep	Air Europa	direct
26 Aug - 26 Sep	KLM
26 Aug - 23 Sep	Air Europa	direct
26 Aug - 25 Sep	Air Europa	direct
26 Aug - 28 Sep	Air Europa	direct
26 Aug - 29 Sep	Air Europa	direct
18 Aug - 21 Aug	Iberia	direct
26 Aug - 30 Aug	Air Europa
24 Aug - 25 Aug	Iberia
16 Aug - 23 Aug	Air France
19 Aug - 26 Aug	KLM
22 Aug - 26 Aug	Air France
19 Aug - 25 Aug	KLM
16 Aug - 24 Aug	Air France
22 Aug - 24 Aug	Air France
26 Aug - 31 Aug	Air Europa

Also check the deals for one-way flights from Madrid to Panama City in August.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Madrid to Panama City in August from 515€

Return flights