AirHint found the following cheapest return flights from Madrid (MAD) to Panama City (PTY) in April 2026 (see full year).

Return flights

02 Apr - 14 Apr	Avianca
17 Apr - 26 Apr	Avianca
02 Apr - 12 Apr	Avianca
03 Apr - 12 Apr	Avianca
09 Apr - 21 Apr	Avianca
02 Apr - 15 Apr	Avianca
15 Apr - 28 Apr	Avianca
26 Apr - 02 May	Avianca
03 Apr - 02 May	Avianca
28 Apr - 08 May	Avianca
17 Apr - 01 May	Avianca
24 Apr - 01 May	Avianca
24 Apr - 03 May	Avianca
25 Apr - 03 May	Avianca
13 Apr - 21 Apr	Avianca
13 Apr - 21 Apr	Air Europa	direct
10 Apr - 17 Apr	Air Europa	direct
24 Apr - 03 May	Iberia	direct
28 Apr - 08 May	Air Europa	direct
17 Apr - 01 May	Iberia	direct

Also check the deals for one-way flights from Madrid to Panama City in April.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Madrid to Panama City in April from 560€

Return flights