AirHint found the following cheapest return flights from Madrid (MAD) to Panama City (PTY) in April 2026 (see full year).

Return flights

13 Apr - 27 Apr	Air Europa	direct
10 Apr - 20 Apr	Air Europa	direct
10 Apr - 19 Apr	Air Europa	direct
10 Apr - 22 Apr	Air Europa	direct
10 Apr - 21 Apr	Air Europa	direct
20 Apr - 27 Apr	Avianca
16 Apr - 27 Apr	Avianca
15 Apr - 26 Apr	Avianca
29 Apr - 11 May	Avianca
15 Apr - 22 Apr	Iberia	direct
17 Apr - 26 Apr	Iberia	direct
19 Apr - 17 May	Iberia	direct
17 Apr - 01 May	Iberia	direct
24 Apr - 01 May	Iberia	direct
24 Apr - 03 May	Iberia	direct
30 Apr - 09 May	Avianca
30 Apr - 15 May	Avianca
26 Apr - 03 May	Iberia	direct
29 Apr - 04 May	Avianca
23 Apr - 03 May	Avianca

Also check the deals for one-way flights from Madrid to Panama City in April.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Madrid to Panama City in April from 533€

Return flights