Cheapest one-way flights from Madrid to Panama City in April from 365€

Best time to book flights for Madrid (MAD) to Panama City (PTY) flights at AirHint

AirHint found the following cheapest one-way flights from Madrid (MAD) to Panama City (PTY) in April 2025 (see full year).

One-Way flights

04 Apr Air Europa direct
06 Apr Air Europa direct
07 Apr Air Europa direct
08 Apr Air Europa direct
20 Apr Air Europa direct
21 Apr Air Europa direct
19 Apr Air Europa direct
09 Apr Air Europa direct
05 Apr Air Europa direct
10 Apr TAP

Also check the deals for return flights from Madrid to Panama City in April.

Skyscanner

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

Book a cheap hotel in Panama City

Cheap car rent in Panama City