Cheapest return flights from Madrid to Panama City in December from 707€

Best time to book flights for Madrid (MAD) to Panama City (PTY) flights at AirHint

AirHint found the following cheapest return flights from Madrid (MAD) to Panama City (PTY) in December 2025 (see full year).

Return flights

01 Dec - 09 Dec Air Europa direct
20 Dec - 29 Dec Iberia direct
01 Dec - 08 Dec Air France
06 Dec - 20 Dec Air France
05 Dec - 14 Dec Air Europa direct
02 Dec - 14 Dec Air France
08 Dec - 11 Jan Iberia
19 Dec - 26 Dec Air Europa direct
01 Dec - 02 Jan Iberia
02 Dec - 14 Dec Air Europa direct
01 Dec - 14 Dec Air France
29 Dec - 03 Jan Iberia direct
27 Dec - 05 Jan Iberia direct
20 Dec - 03 Jan Iberia direct
22 Dec - 30 Dec Iberia
16 Dec - 03 Jan Iberia
20 Dec - 02 Jan Turkish Airlines
26 Dec - 04 Jan Turkish Airlines
23 Dec - 01 Jan Turkish Airlines
24 Dec - 02 Jan Turkish Airlines

Also check the deals for one-way flights from Madrid to Panama City in December.

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The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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