AirHint found the following cheapest one-way flights from Madrid (MAD) to Panama City (PTY) in December 2025 (see full year).
One-Way flights
| 30 Dec | Ryanair | ||
| 13 Dec | Ryanair | ||
| 03 Dec | Transavia France | ||
| 29 Dec | Wizz Air Malta | ||
| 31 Dec | Avianca | ||
| 15 Dec | Transavia France | ||
| 10 Dec | Iberia | ||
| 04 Dec | Avianca | ||
| 13 Dec | Air Europa | direct | |
| 06 Dec | Air Europa | direct |
Also check the deals for return flights from Madrid to Panama City in December.
The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.
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