AirHint found the following cheapest one-way flights from Madrid (MAD) to Panama City (PTY) in December 2025 (see full year).
One-Way flights
| 30 Dec | TAP | ||
| 28 Dec | Air Europa | ||
| 31 Dec | TAP | ||
| 29 Dec | TAP | ||
| 27 Dec | Iberia | ||
| 26 Dec | Iberia | ||
| 31 Dec | Air Europa | direct | |
| 30 Dec | Air Europa | direct | |
| 25 Dec | Iberia | ||
| 28 Dec | Air Europa | direct |
Also check the deals for return flights from Madrid to Panama City in December.
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