AirHint found the following cheapest one-way flights from Madrid (MAD) to Panama City (PTY) in December 2025 (see full year).
One-Way flights
| 07 Dec | Ryanair | ||
| 12 Dec | Ryanair | ||
| 09 Dec | Ryanair | ||
| 13 Dec | Ryanair | ||
| 30 Dec | Ryanair | ||
| 04 Dec | Air Arabia Maroc | ||
| 05 Dec | Ryanair | ||
| 08 Dec | Ryanair | ||
| 29 Dec | easyJet | ||
| 25 Dec | Avianca |
Also check the deals for return flights from Madrid to Panama City in December.
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The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.
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