Cheapest one-way flights from Madrid to Panama City in December from 424€

AirHint found the following cheapest one-way flights from Madrid (MAD) to Panama City (PTY) in December 2026 (see full year).

One-Way flights

27 Dec Avianca
28 Dec Avianca
07 Dec Avianca
07 Dec Air Europa direct
15 Dec Air Europa direct
20 Dec Wizz Air Malta
21 Dec Ryanair
28 Dec Air Europa direct
27 Dec Air Europa direct
21 Dec Iberia direct

Also check the deals for return flights from Madrid to Panama City in December.

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The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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