AirHint found the following cheapest return flights from Madrid (MAD) to Panama City (PTY) in November 2025 (see full year).

Return flights

15 Nov - 28 Nov	United
07 Nov - 17 Nov	United
15 Nov - 05 Dec	United
21 Nov - 07 Dec	United
26 Nov - 07 Dec	United
27 Nov - 07 Dec	United
21 Nov - 01 Dec	United
07 Nov - 21 Nov	United
05 Nov - 14 Nov	United
06 Nov - 14 Nov	United
07 Nov - 22 Nov	United
06 Nov - 10 Nov	Air Europa	direct
07 Nov - 17 Nov	Air Europa	direct
22 Nov - 30 Nov	Air Europa	direct
21 Nov - 07 Dec	Air Europa	direct
21 Nov - 01 Dec	Air Europa	direct
06 Nov - 14 Nov	Air Europa	direct
18 Nov - 08 Dec	Air France
18 Nov - 08 Dec	Air Europa	direct
29 Nov - 08 Dec	Iberia	direct

Also check the deals for one-way flights from Madrid to Panama City in November.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Madrid to Panama City in November from 585€

Return flights