AirHint found the following cheapest return flights from Madrid (MAD) to Panama City (PTY) in November 2025 (see full year).

Return flights

06 Nov - 15 Nov	Avianca
09 Nov - 19 Nov	Avianca
10 Nov - 22 Nov	Avianca
08 Nov - 16 Nov	Avianca
12 Nov - 19 Nov	Avianca
07 Nov - 16 Nov	Avianca
10 Nov - 16 Nov	Avianca
10 Nov - 20 Nov	Avianca
14 Nov - 24 Nov	Avianca
14 Nov - 23 Nov	Avianca
26 Nov - 07 Dec	Avianca
21 Nov - 07 Dec	Avianca
20 Nov - 04 Dec	Avianca
24 Nov - 07 Dec	Avianca
24 Nov - 04 Dec	Avianca
26 Nov - 13 Dec	Avianca
28 Nov - 06 Dec	Avianca
20 Nov - 04 Dec	Air Europa	direct
29 Nov - 12 Dec	Avianca
29 Nov - 13 Dec	Avianca

Also check the deals for one-way flights from Madrid to Panama City in November.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Madrid to Panama City in November from 561€

Return flights