AirHint found the following cheapest return flights from Madrid (MAD) to Panama City (PTY) in November 2025 (see full year).

Return flights

25 Nov - 28 Nov	Air France
08 Nov - 24 Nov	Avianca
23 Nov - 30 Nov	Avianca
01 Nov - 10 Nov	Avianca
02 Nov - 14 Nov	Avianca
15 Nov - 22 Nov	Avianca
08 Nov - 15 Nov	Avianca
14 Nov - 23 Nov	Avianca
20 Nov - 25 Nov	Avianca
04 Nov - 12 Nov	Avianca
06 Nov - 06 Dec	Air Europa	direct
15 Nov - 01 Dec	Air Europa	direct
21 Nov - 01 Dec	Air Europa	direct
22 Nov - 07 Dec	Air France
26 Nov - 03 Dec	Iberia	direct
25 Nov - 02 Dec	Air Europa	direct
14 Nov - 08 Dec	Air Europa	direct
18 Nov - 08 Dec	Avianca
26 Nov - 08 Dec	Iberia	direct
22 Nov - 07 Dec	Air Europa	direct

Also check the deals for one-way flights from Madrid to Panama City in November.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Madrid to Panama City in November from 505€

Return flights