AirHint found the following cheapest return flights from Madrid (MAD) to Panama City (PTY) in October 2025 (see full year).

Return flights

20 Oct - 27 Oct	Iberia	direct
20 Oct - 05 Nov	Iberia	direct
18 Oct - 25 Oct	Iberia	direct
16 Oct - 10 Nov	Iberia	direct
20 Oct - 23 Oct	Iberia	direct
29 Oct - 09 Nov	Avianca
31 Oct - 08 Nov	Avianca
21 Oct - 03 Nov	Avianca
30 Oct - 10 Nov	Avianca
30 Oct - 20 Nov	Avianca
30 Oct - 13 Nov	Avianca
31 Oct - 14 Nov	Avianca
24 Oct - 07 Nov	Avianca
20 Oct - 24 Oct	Iberia
18 Oct - 29 Oct	Ryanair
18 Oct - 28 Oct	Ryanair
24 Oct - 27 Oct	Avianca
18 Oct - 26 Oct	Iberia
25 Oct - 29 Oct	Ryanair
25 Oct - 30 Oct	Iberia Express

Also check the deals for one-way flights from Madrid to Panama City in October.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Madrid to Panama City in October from 611€

Return flights