AirHint found the following cheapest return flights from Madrid (MAD) to Panama City (PTY) in October 2025 (see full year).

Return flights

01 Oct - 08 Oct	Air France
10 Oct - 19 Oct	Air Europa	direct
14 Oct - 25 Oct	Iberia	direct
27 Oct - 05 Nov	Iberia	direct
04 Oct - 19 Oct	Air France
10 Oct - 20 Oct	Avianca
24 Oct - 07 Nov	Avianca
31 Oct - 09 Nov	Avianca
30 Oct - 06 Nov	Avianca
29 Oct - 09 Nov	Avianca
09 Oct - 16 Oct	Iberia	direct
06 Oct - 20 Oct	Air Europa	direct
10 Oct - 20 Oct	Air Europa	direct
17 Oct - 27 Oct	Air Europa	direct
11 Oct - 25 Oct	Air Europa	direct
24 Oct - 07 Nov	Air Europa	direct
17 Oct - 04 Nov	Air Europa	direct
23 Oct - 03 Nov	Iberia	direct
16 Oct - 02 Nov	United
14 Oct - 25 Nov	Air Europa	direct

Also check the deals for one-way flights from Madrid to Panama City in October.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Madrid to Panama City in October from 591€

Return flights