AirHint found the following cheapest return flights from Madrid (MAD) to Panama City (PTY) in October 2025 (see full year).

Return flights

20 Oct - 27 Oct	Air Europa	direct
17 Oct - 26 Oct	Air Europa	direct
13 Oct - 19 Oct	Air Europa	direct
29 Oct - 08 Nov	Iberia	direct
29 Oct - 26 Nov	Iberia	direct
27 Oct - 10 Nov	Iberia	direct
24 Oct - 01 Nov	Air Europa	direct
28 Oct - 08 Nov	Air Europa	direct
30 Oct - 10 Nov	Air Europa	direct
30 Oct - 14 Nov	Air Europa	direct
13 Oct - 26 Oct	Air Europa	direct
25 Oct - 08 Nov	Air Europa	direct
04 Oct - 19 Oct	Air France
31 Oct - 09 Nov	United
02 Oct - 19 Oct	Air France
28 Oct - 11 Nov	Air France
19 Oct - 31 Oct	Avianca
16 Oct - 19 Oct	Avianca
18 Oct - 25 Oct	Avianca
18 Oct - 26 Oct	Avianca

Also check the deals for one-way flights from Madrid to Panama City in October.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Madrid to Panama City in October from 604€

Return flights