AirHint found the following cheapest return flights from Madrid (MAD) to Istanbul (IST) in December 2026 (see full year).

Return flights

05 Dec - 06 Jan	Air Serbia
03 Dec - 09 Dec	Air Europa
02 Dec - 09 Dec	Air Europa
02 Dec - 07 Dec	Air Europa
07 Dec - 12 Dec	Wizz Air Malta
30 Dec - 05 Jan	Iberia
20 Dec - 09 Jan	Air Serbia
08 Dec - 12 Dec	Wizz Air
03 Dec - 06 Dec	Air Serbia
05 Dec - 12 Dec	Air Serbia
05 Dec - 08 Dec	Air Serbia
04 Dec - 08 Dec	Wizz Air UK
04 Dec - 09 Dec	Wizz Air UK
22 Dec - 04 Jan	TAROM
18 Dec - 09 Jan	Wizz Air
05 Dec - 06 Jan	Air Europa	direct
20 Dec - 09 Jan	Air Europa	direct
18 Dec - 09 Jan	Air Europa	direct
30 Dec - 05 Jan	Air Europa	direct

Also check the deals for one-way flights from Madrid to Istanbul in December.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Madrid to Istanbul in December from 171€

Return flights