Cheapest one-way flights from Madrid to Istanbul in December from 52€

AirHint found the following cheapest one-way flights from Madrid (MAD) to Istanbul (IST) in December 2025 (see full year).

One-Way flights

16 Dec AJet
09 Dec AJet
10 Dec easyJet
12 Dec Pegasus Airlines
17 Dec Pegasus Airlines
15 Dec Pegasus Airlines direct
18 Dec Wizz Air
16 Dec Pegasus Airlines direct
17 Dec Pegasus Airlines direct
10 Dec Pegasus Airlines direct

Also check the deals for return flights from Madrid to Istanbul in December.

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The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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