AirHint found the following cheapest return flights from Madrid (MAD) to Guayaquil (GYE) in April 2026 (see full year).

Return flights

16 Apr - 25 Apr	Avianca
17 Apr - 26 Apr	Avianca
17 Apr - 25 Apr	Avianca
09 Apr - 12 Apr	Avianca
16 Apr - 14 May	Avianca
15 Apr - 06 May	Avianca
19 Apr - 27 Apr	Avianca
09 Apr - 20 Apr	Avianca
17 Apr - 03 May	Avianca
16 Apr - 07 May	Avianca
16 Apr - 30 Apr	Iberia	direct
09 Apr - 30 Apr	Iberia	direct
16 Apr - 07 May	Iberia	direct
16 Apr - 14 May	Iberia	direct
15 Apr - 06 May	Iberia	direct
10 Apr - 29 Apr	LATAM Airlines Group
01 Apr - 12 Apr	Avianca
03 Apr - 03 May	Avianca
16 Apr - 02 May	Avianca
17 Apr - 03 May	Air Europa	direct

Also check the deals for one-way flights from Madrid to Guayaquil in April.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Madrid to Guayaquil in April from 564€

Return flights