AirHint found the following cheapest return flights from Houston (HOU) to Santiago (SCL) in December 2025 (see full year).

Return flights

02 Dec - 06 Dec	Spirit Airlines
10 Dec - 22 Dec	Spirit Airlines
29 Dec - 14 Jan	Spirit Airlines
28 Dec - 09 Jan	Spirit Airlines
30 Dec - 07 Jan	Spirit Airlines
19 Dec - 26 Dec	Frontier Airlines
29 Dec - 14 Jan	United	direct
17 Dec - 05 Jan	Spirit Airlines
17 Dec - 04 Jan	Spirit Airlines
15 Dec - 22 Dec	American Airlines
10 Dec - 22 Dec	United	direct
12 Dec - 19 Dec	Delta
14 Dec - 21 Dec	Delta
30 Dec - 07 Jan	United	direct
19 Dec - 26 Dec	United	direct
28 Dec - 09 Jan	United	direct
01 Dec - 08 Dec	United	direct

Also check the deals for one-way flights from Houston to Santiago in December.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Houston to Santiago in December from 467€

Return flights