Cheapest one-way flights from Houston to Santiago in December from 206€

AirHint found the following cheapest one-way flights from Houston (HOU) to Santiago (SCL) in December 2025 (see full year).

One-Way flights

05 Dec Spirit Airlines
13 Dec Spirit Airlines
14 Dec Spirit Airlines
15 Dec Frontier Airlines
22 Dec Frontier Airlines
19 Dec Frontier Airlines
20 Dec Frontier Airlines
15 Dec United direct
22 Dec United direct
14 Dec United direct

Also check the deals for return flights from Houston to Santiago in December.

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The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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