AirHint found the following cheapest return flights from Amsterdam (AMS) to Panama City (PTY) in December 2025 (see full year).

Return flights

07 Dec - 15 Dec	United
30 Dec - 22 Jan	United
30 Dec - 21 Jan	United
12 Dec - 22 Jan	United
30 Dec - 20 Jan	United
29 Dec - 21 Jan	United
15 Dec - 27 Dec	United
25 Dec - 08 Jan	United
12 Dec - 09 Jan	United
14 Dec - 22 Jan	United
29 Dec - 07 Jan	United
14 Dec - 11 Jan	United
01 Dec - 10 Dec	Delta
10 Dec - 27 Dec	Lufthansa
22 Dec - 31 Dec	United
01 Dec - 10 Dec	KLM	direct
16 Dec - 27 Dec	Turkish Airlines
10 Dec - 27 Dec	KLM	direct
23 Dec - 30 Dec	Delta
16 Dec - 27 Dec	KLM	direct

Also check the deals for one-way flights from Amsterdam to Panama City in December.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Amsterdam to Panama City in December from 568€

Return flights