AirHint found the following cheapest return flights from Amsterdam (AMS) to Panama City (PTY) in December 2025 (see full year).

Return flights

12 Dec - 23 Jan	United
30 Dec - 12 Jan	United
12 Dec - 23 Dec	United
04 Dec - 18 Dec	United
13 Dec - 24 Jan	United
13 Dec - 23 Jan	United
14 Dec - 23 Dec	United
28 Dec - 07 Jan	United
29 Dec - 11 Jan	United
06 Dec - 22 Dec	United
05 Dec - 22 Dec	United
26 Dec - 11 Jan	Lufthansa
26 Dec - 10 Jan	Lufthansa
27 Dec - 10 Jan	Lufthansa
24 Dec - 11 Jan	Delta

Also check the deals for one-way flights from Amsterdam to Panama City in December.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

Book a cheap hotel in Panama City

Cheap car rent in Panama City

Cheapest return flights from Amsterdam to Panama City in December from 586€

Return flights