Cheapest one-way flights from Santiago to Madrid in October from 442€

Best time to book flights for Santiago (SCL) to Madrid (MAD) flights at AirHint

AirHint found the following cheapest one-way flights from Santiago (SCL) to Madrid (MAD) in October 2025 (see full year).

One-Way flights

01 Oct LATAM Airlines Group
16 Oct LATAM Airlines Group
03 Oct Avianca
15 Oct LATAM Airlines Group
08 Oct LATAM Airlines Group
09 Oct LATAM Airlines Group
06 Oct Avianca
30 Oct Avianca
05 Oct Avianca
11 Oct Avianca

Also check the deals for return flights from Santiago to Madrid in October.

Skyscanner

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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