Cheapest one-way flights from Chicago to Rome in April from 344€

AirHint found the following cheapest one-way flights from Chicago (MDW) to Rome (FCO) in April 2026 (see full year).

One-Way flights

11 Apr Frontier Airlines
20 Apr Air France
15 Apr Delta
21 Apr Air France
16 Apr Air France
12 Apr Frontier Airlines
08 Apr Frontier Airlines
09 Apr Frontier Airlines
03 Apr Frontier Airlines
05 Apr Frontier Airlines

Also check the deals for return flights from Chicago to Rome in April.

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The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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