AirHint found the following cheapest return flights from Santa Cruz (VVI) to Madrid (MAD) in September 2025 (see full year).

Return flights

29 Sep - 22 Oct	Iberia	direct
22 Sep - 22 Oct	Iberia	direct
13 Sep - 29 Oct	Iberia	direct
08 Sep - 22 Sep	Air Europa	direct
23 Sep - 23 Oct	Avianca
21 Sep - 29 Sep	Avianca
22 Sep - 29 Sep	Avianca
22 Sep - 28 Sep	Avianca
23 Sep - 08 Oct	Avianca
23 Sep - 02 Oct	Avianca
08 Sep - 19 Sep	Avianca
11 Sep - 08 Oct	Air Europa	direct
01 Sep - 08 Sep	Air Europa	direct
22 Sep - 28 Sep	Air Europa	direct
20 Sep - 30 Sep	Avianca
19 Sep - 29 Sep	Avianca
15 Sep - 01 Oct	Air Europa	direct
04 Sep - 25 Sep	Boliviana de Aviacion
07 Sep - 02 Oct	Avianca
06 Sep - 15 Oct	Boliviana de Aviacion

Also check the deals for one-way flights from Santa Cruz to Madrid in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Santa Cruz to Madrid in September from 708€

Return flights