AirHint found the following cheapest return flights from Quito (UIO) to Santiago (SCL) in September 2025 (see full year).

Return flights

10 Sep - 26 Sep	JetSmart
10 Sep - 21 Sep	JetSmart
10 Sep - 24 Sep	JetSmart
28 Sep - 17 Oct	JetSmart
28 Sep - 19 Oct	JetSmart
03 Sep - 30 Sep	Avianca
03 Sep - 29 Sep	Avianca
02 Sep - 29 Sep	Avianca
19 Sep - 29 Sep	Avianca
14 Sep - 18 Sep	Avianca
21 Sep - 02 Oct	JetSmart
22 Sep - 02 Oct	Copa
22 Sep - 30 Sep	Copa
15 Sep - 04 Oct	Copa
20 Sep - 29 Sep	LATAM Airlines Group

Also check the deals for one-way flights from Quito to Santiago in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Quito to Santiago in September from 322€

Return flights