AirHint found the following cheapest return flights from Quito (UIO) to Santiago (SCL) in September 2025 (see full year).

Return flights

12 Sep - 28 Sep	JetSmart
12 Sep - 01 Oct	JetSmart
12 Sep - 24 Sep	JetSmart
12 Sep - 03 Oct	JetSmart
05 Sep - 10 Sep	JetSmart
14 Sep - 28 Sep	JetSmart
17 Sep - 01 Oct	JetSmart
14 Sep - 01 Oct	JetSmart
05 Sep - 08 Sep	JetSmart
10 Sep - 01 Oct	JetSmart
17 Sep - 08 Oct	JetSmart
17 Sep - 28 Sep	JetSmart
14 Sep - 24 Sep	JetSmart
28 Sep - 10 Oct	JetSmart
28 Sep - 01 Oct	JetSmart
17 Sep - 24 Sep	JetSmart
05 Sep - 24 Sep	JetSmart
17 Sep - 03 Oct	JetSmart
14 Sep - 03 Oct	JetSmart
10 Sep - 28 Sep	JetSmart

Also check the deals for one-way flights from Quito to Santiago in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Quito to Santiago in September from 282€

Return flights