AirHint found the following cheapest return flights from Quito (UIO) to Santiago (SCL) in April 2026 (see full year).

Return flights

12 Apr - 26 Apr	JetSmart
15 Apr - 26 Apr	JetSmart
17 Apr - 26 Apr	JetSmart
15 Apr - 06 May	JetSmart
17 Apr - 06 May	JetSmart
03 Apr - 22 Apr	JetSmart
12 Apr - 19 Apr	JetSmart
22 Apr - 26 Apr	JetSmart
08 Apr - 26 Apr	JetSmart
12 Apr - 22 Apr	JetSmart
12 Apr - 15 Apr	JetSmart
15 Apr - 19 Apr	JetSmart
22 Apr - 06 May	JetSmart
19 Apr - 06 May	JetSmart
26 Apr - 15 May	JetSmart
26 Apr - 06 May	JetSmart

Also check the deals for one-way flights from Quito to Santiago in April.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Quito to Santiago in April from 264€

Return flights