AirHint found the following cheapest return flights from Quito (UIO) to Santiago (SCL) in November 2025 (see full year).

Return flights

26 Nov - 06 Dec	JetSmart
13 Nov - 19 Nov	JetSmart
19 Nov - 21 Nov	JetSmart
13 Nov - 21 Nov	JetSmart
23 Nov - 26 Nov	Avianca
18 Nov - 22 Nov	Avianca
15 Nov - 20 Nov	Copa
23 Nov - 28 Nov	Avianca
19 Nov - 23 Nov	JetSmart
13 Nov - 20 Nov	Copa
11 Nov - 18 Nov	Copa
26 Nov - 03 Dec	JetSmart
26 Nov - 07 Dec	JetSmart
26 Nov - 10 Dec	JetSmart
19 Nov - 03 Dec	JetSmart
13 Nov - 03 Dec	JetSmart
19 Nov - 07 Dec	JetSmart
27 Nov - 01 Dec	Avianca
19 Nov - 10 Dec	JetSmart
23 Nov - 07 Dec	JetSmart

Also check the deals for one-way flights from Quito to Santiago in November.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Quito to Santiago in November from 384€

Return flights