AirHint found the following cheapest return flights from Quito (UIO) to Santiago (SCL) in October 2025 (see full year).

Return flights

01 Oct - 22 Oct	JetSmart
05 Oct - 22 Oct	JetSmart
12 Oct - 22 Oct	JetSmart
08 Oct - 22 Oct	JetSmart
15 Oct - 22 Oct	JetSmart
01 Oct - 10 Oct	JetSmart
05 Oct - 10 Oct	JetSmart
03 Oct - 22 Oct	JetSmart
01 Oct - 15 Oct	JetSmart
01 Oct - 08 Oct	JetSmart
14 Oct - 14 Nov	Avianca
15 Oct - 15 Nov	Avianca
28 Oct - 04 Nov	Avianca
31 Oct - 13 Nov	JetSmart
01 Oct - 01 Nov	Copa

Also check the deals for one-way flights from Quito to Santiago in October.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Quito to Santiago in October from 269€

Return flights