AirHint found the following cheapest return flights from Quito (UIO) to Panama City (PTY) in September 2025 (see full year).

Return flights

28 Sep - 02 Oct	Avianca
20 Sep - 22 Sep	Avianca
30 Sep - 05 Oct	Avianca
29 Sep - 05 Oct	Avianca
28 Sep - 03 Oct	Avianca
30 Sep - 07 Oct	Avianca
16 Sep - 20 Sep	Avianca
30 Sep - 03 Oct	Avianca
25 Sep - 25 Sep	Avianca
20 Sep - 27 Sep	Avianca
24 Sep - 01 Oct	Avianca
19 Sep - 23 Sep	Avianca
17 Sep - 20 Sep	Avianca
26 Sep - 30 Sep	Avianca
14 Sep - 21 Sep	Avianca
14 Sep - 19 Sep	Avianca
13 Sep - 20 Sep	Avianca
29 Sep - 09 Oct	Avianca
29 Sep - 09 Oct	Copa	direct
30 Sep - 07 Oct	Copa	direct

Also check the deals for one-way flights from Quito to Panama City in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Quito to Panama City in September from 374€

Return flights