AirHint found the following cheapest return flights from Quito (UIO) to Panama City (PTY) in December 2025 (see full year).

Return flights

25 Dec - 29 Dec	Avianca
20 Dec - 27 Dec	Avianca
26 Dec - 01 Jan	Avianca
25 Dec - 28 Dec	Avianca
09 Dec - 12 Dec	Avianca
08 Dec - 11 Dec	Avianca
14 Dec - 17 Dec	Avianca
15 Dec - 17 Dec	Avianca
10 Dec - 17 Dec	Avianca
24 Dec - 28 Dec	Avianca
20 Dec - 30 Dec	Avianca
27 Dec - 04 Jan	Avianca
26 Dec - 01 Jan	Copa	direct
31 Dec - 04 Jan	Copa	direct
30 Dec - 04 Jan	Copa	direct
27 Dec - 04 Jan	Copa	direct

Also check the deals for one-way flights from Quito to Panama City in December.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Quito to Panama City in December from 363€

Return flights