AirHint found the following cheapest return flights from Quito (UIO) to Panama City (PTY) in December 2025 (see full year).

Return flights

24 Dec - 28 Dec	Avianca
24 Dec - 07 Jan	Avianca
01 Dec - 01 Jan	Avianca
24 Dec - 29 Dec	Avianca
05 Dec - 08 Dec	Avianca
15 Dec - 20 Dec	Copa	direct
24 Dec - 28 Dec	Copa	direct
05 Dec - 08 Dec	Copa	direct
25 Dec - 29 Dec	Avianca
27 Dec - 01 Jan	Avianca
26 Dec - 30 Dec	Copa	direct
25 Dec - 29 Dec	Copa	direct
24 Dec - 29 Dec	Copa	direct
26 Dec - 04 Jan	Copa	direct
25 Dec - 04 Jan	Copa	direct
24 Dec - 07 Jan	Copa	direct
27 Dec - 01 Jan	Copa	direct
01 Dec - 01 Jan	Copa	direct
21 Dec - 04 Jan	Avianca
24 Dec - 02 Jan	Avianca

Also check the deals for one-way flights from Quito to Panama City in December.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Quito to Panama City in December from 351€

Return flights