AirHint found the following cheapest return flights from Quito (UIO) to Panama City (PTY) in December 2025 (see full year).

Return flights

01 Dec - 01 Jan	Avianca
09 Dec - 16 Dec	Avianca
02 Dec - 05 Dec	Avianca
04 Dec - 10 Dec	Avianca
05 Dec - 09 Dec	Avianca
06 Dec - 09 Dec	Avianca
04 Dec - 07 Dec	Avianca
08 Dec - 12 Dec	Avianca
08 Dec - 15 Dec	Avianca
23 Dec - 01 Jan	Avianca
21 Dec - 27 Dec	Avianca
21 Dec - 28 Dec	Avianca
29 Dec - 01 Jan	Avianca
22 Dec - 05 Jan	Copa	direct
22 Dec - 04 Jan	Avianca
25 Dec - 02 Jan	Avianca
29 Dec - 02 Jan	Avianca
29 Dec - 04 Jan	Avianca
30 Dec - 03 Jan	Avianca
29 Dec - 01 Jan	Copa	direct

Also check the deals for one-way flights from Quito to Panama City in December.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Quito to Panama City in December from 343€

Return flights