AirHint found the following cheapest return flights from Quito (UIO) to Panama City (PTY) in October 2025 (see full year).

Return flights

01 Oct - 03 Oct	Avianca
01 Oct - 01 Oct	Avianca
20 Oct - 21 Oct	Avianca
22 Oct - 01 Nov	Avianca
09 Oct - 13 Oct	Avianca
13 Oct - 15 Oct	Avianca
12 Oct - 17 Oct	Avianca
09 Oct - 12 Oct	Avianca
01 Oct - 03 Oct	Copa	direct
21 Oct - 26 Oct	Euroairlines, S.L.	direct
16 Oct - 19 Oct	Euroairlines, S.L.	direct
22 Oct - 01 Nov	Copa	direct
22 Oct - 04 Nov	Avianca
22 Oct - 04 Nov	Copa	direct

Also check the deals for one-way flights from Quito to Panama City in October.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Quito to Panama City in October from 388€

Return flights