AirHint found the following cheapest return flights from Quito (UIO) to Panama City (PTY) in October 2025 (see full year).

Return flights

01 Oct - 01 Oct	Avianca
08 Oct - 11 Oct	Avianca
09 Oct - 16 Oct	Avianca
26 Oct - 30 Oct	Euroairlines, S.L.	direct
10 Oct - 16 Oct	Avianca
01 Oct - 05 Oct	Avianca
19 Oct - 25 Oct	Avianca
20 Oct - 22 Oct	Avianca
03 Oct - 05 Oct	Avianca
22 Oct - 26 Oct	Avianca
25 Oct - 30 Nov	Avianca
31 Oct - 05 Nov	Copa	direct
30 Oct - 03 Nov	Copa	direct
30 Oct - 03 Nov	Avianca
31 Oct - 04 Nov	Copa	direct
25 Oct - 30 Nov	Copa	direct

Also check the deals for one-way flights from Quito to Panama City in October.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Quito to Panama City in October from 374€

Return flights