AirHint found the following cheapest return flights from Quito (UIO) to Madrid (MAD) in September 2025 (see full year).

Return flights

17 Sep - 01 Oct	Avianca
26 Sep - 12 Oct	Avianca
23 Sep - 08 Oct	Avianca
02 Sep - 16 Sep	LATAM Airlines Group
22 Sep - 26 Oct	Avianca
24 Sep - 12 Oct	Avianca
15 Sep - 28 Sep	LATAM Airlines Group
22 Sep - 30 Sep	Avianca
24 Sep - 08 Oct	Avianca
24 Sep - 29 Sep	Avianca
10 Sep - 24 Sep	Avianca
10 Sep - 23 Sep	Avianca
17 Sep - 24 Sep	Avianca
10 Sep - 26 Sep	Avianca
10 Sep - 22 Sep	Avianca
10 Sep - 27 Sep	Avianca
14 Sep - 03 Oct	Avianca
19 Sep - 18 Oct	Avianca
14 Sep - 14 Oct	LATAM Airlines Group
11 Sep - 01 Oct	Avianca

Also check the deals for one-way flights from Quito to Madrid in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Quito to Madrid in September from 752€

Return flights