AirHint found the following cheapest return flights from Quito (UIO) to Madrid (MAD) in October 2025 (see full year).

Return flights

11 Oct - 25 Oct	Avianca
20 Oct - 21 Nov	Iberia
13 Oct - 24 Oct	Iberia
07 Oct - 30 Oct	Avianca
16 Oct - 03 Nov	Avianca
20 Oct - 05 Nov	Avianca
09 Oct - 23 Oct	Avianca
11 Oct - 25 Oct	Iberia	direct
16 Oct - 24 Oct	Iberia	direct
16 Oct - 23 Oct	Iberia	direct
16 Oct - 28 Oct	Avianca
15 Oct - 02 Nov	Avianca
04 Oct - 09 Oct	Copa
24 Oct - 09 Nov	Iberia
09 Oct - 23 Oct	Air Europa	direct
23 Oct - 06 Nov	Air Europa	direct
05 Oct - 30 Nov	Avianca
30 Oct - 06 Nov	Air Europa	direct
22 Oct - 13 Nov	Iberia	direct
22 Oct - 06 Nov	Iberia

Also check the deals for one-way flights from Quito to Madrid in October.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Quito to Madrid in October from 752€

Return flights