AirHint found the following cheapest return flights from Quito (UIO) to Madrid (MAD) in October 2025 (see full year).

Return flights

24 Oct - 09 Nov	Avianca
30 Oct - 14 Nov	Avianca
27 Oct - 05 Nov	Avianca
14 Oct - 29 Oct	Avianca
02 Oct - 20 Oct	Avianca
17 Oct - 30 Oct	Avianca
17 Oct - 31 Oct	Avianca
13 Oct - 27 Oct	Avianca
19 Oct - 26 Oct	Avianca
10 Oct - 05 Nov	Avianca
19 Oct - 03 Nov	Avianca
27 Oct - 05 Nov	Iberia	direct
06 Oct - 20 Oct	Avianca
07 Oct - 30 Oct	Air Europa	direct
10 Oct - 01 Nov	Avianca
09 Oct - 26 Oct	Avianca
09 Oct - 27 Oct	Avianca
06 Oct - 06 Nov	LATAM Airlines Group
17 Oct - 04 Nov	Avianca
24 Oct - 08 Nov	Avianca

Also check the deals for one-way flights from Quito to Madrid in October.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Quito to Madrid in October from 750€

Return flights